Sex as a Biological Covariate in QTL Studies
Goals of this webinar (trait variance to QTL):
Review QTL mapping
Understand the role of sex in QTL study design
Use sex as a covariate in QTL analysis
Understand X chromosome segregation in crosses
Make adjustments for X chromosome in QTL analysis
Presented by:
Dr. Saunak Sen
Professor and Chief of Biostatistics
Department of Preventative Medicine
University of Tennessee Health Science Center
Identifying genes from QTL using RNA expression and the PhenoGen website (http://phenogen.org)
Goals of this webinar (candidate genes to causal variants):
Demonstrate how to use the PhenoGen website to identify transcripts:
Physically located within a QTL
Physically located within a QTL and expressed in brain
With a brain cis eQTL within the QTL
With any brain eQTL within the QTL
Within a co-expression network controlled from the same region as the QTL
Presented by:
Dr. Laura Saba
Associate Professor
Department of Pharmaceutical Sciences
University of Colorado Anschutz Medical Campus
From Candidate Genes to Causal Variants—Strategies for and Examples of Identifying Genes and Sequence Variants in Rodent Populations
Goals of this webinar (candidate genes to causal variants):
To understand when it is practical or (just as often) not practical to try to "clone" the gene or nucleotide variant modulating trait variants
To understand that defining the crucial causal nucleotide variant is usually a bonus and often not for the translational or even mechanistic utility of discoveries.
To review new sequence-based methods to identify common and rare variants—the reduced complexity cross and epoch-effects in reference populations
Presented by:
Dr. Rob Williams
Professor and Chair
Department of Genetics, Genomics, and Informatics
University of Tennessee Health Science Center
Introduction to expression (e)QTL and their role in connecting QTL to genes and molecular networks
Goals of this webinar (QTL to gene/molecular networks):
Define eQTL
Examine the role of eQTL in the relationship of genes and molecular networks with phenotypic QTL
eQTL for co-expression networks
Presented by:
Dr. Laura Saba
Associate Professor
Department of Pharmaceutical Sciences
University of Colorado Anschutz Medical Campus
Mapping Addiction and Behavioral Traits and Getting at Causal Gene Variants with GeneNetwork
Goals of this webinar (QTL to gene variant):
Demonstrate mapping a quantitative trait using GeneNetwork (GN)
Explore GN tools to identify genes and genetics variants related to a QTL
Presented by:
Dr. Rob Williams
Professor and Chair
Department of Genetics, Genomics, and Informatics
University of Tennessee Health Science Center
Introduction to Quantitative Trait Locus (QTL) Mapping
Presented By:
Saunak Sen
Professor and Chief of Biostatistics
Department of Preventive Medicine
University of Tennessee Health Science Center
sen@uthsc.edu ~ @saunaksen ~ http://www.senresearch.org
Goals of Webinar:
What is a quantitative trait locus (QTL)?
Why are we interested in them?
What are genome scans and how do they help find QTL?
What are the strengths and limitations of QTL mapping?